homocysteine intracerebroventricular injection induces apoptosis in the substantia nigra cells and parkinson like behavior in rat

نویسندگان

amin ataie cellular and molecular biology research center (cmbrc), babol university of medical science, babol, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (babol university of medical sciences)

ramin ataie pharmaceutical sciences research center, department of pharmacology and toxicology mazandaran, university of medical sciences, sari, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (mazandaran university of medical sciences)

zahra mansouri neuroscience research center. shahid beheshti university of medical science, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences)

seyed mohsen aghajanpour cellular and molecular biology research center (cmbrc), babol university of medical science, babol, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (babol university of medical sciences)

چکیده

parkinson's disease is a degenerative disorder of the central nervous system. the motor symptoms of parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain the cause of this cell death is unknown. homocysteine (hcy) is a non-protein amino acid. it is a homologue of the amino acid cysteine. the elevated levels of homocysteine in plasma have been associated with a number of disease states. hcy (2 µmol / µl) was injected intracerebroventricular (i.c.v) in rats, five days later, the locomotor activity was measured with open field apparatus, also apoptosis was investigated in substantia nigra cells by immunohistochemical analysis. hcy could decrease locomotor activities significantly in rats as well as it could induce apoptosis in substantia nigra cells. these results suggest that hcy is a neurotoxic metabolite and may induce cell death in some nuclei in the brain.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Homocysteine intracerebroventricular injection induces apoptosis in the Substantia Nigra cells and Parkinson like behavior in rat

Parkinson's disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain the cause of this cell death is unknown. Homocysteine (Hcy) is a non-protein amino acid. It is a homologue of the amino acid cysteine. The elevated levels of homocysteine in p...

متن کامل

Homocysteine Intracerebroventricular Injection Induces Apoptosis in the Substantia Nigra Cells and Parkinson's Disease LikeBehavior in Rats

Parkinson's disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of this cell death is unknown. Homocysteine (Hcy) is a non-protein amino acid. It is a homologue of the amino acid cysteine. The elevated levels of homocysteine in p...

متن کامل

Chronic consumption of cassava juice induces cellular stress in rat substantia nigra

Objective(s): Cassava (Manihot esculenta Crantz) contains cyanogenic glycosides (linamarin and lotaustralin) that have been associated with neurological disorders in humans and rats. In basal ganglia, the dopaminergic neurons of substantia nigra pars compacta (SNpc) show high cytotoxic susceptibility; therefore, the chronic consumption of cassava (CCC) could induce neu...

متن کامل

Interaction of Memantine with Homocysteine on the Apoptosis in the Rat Hippocampus cells

It has been hypothesized that elevated plasma Homocysteine (Hcy) plays a role in the pathogenesis of Alzheimer’s disease (AD) and age-related cognitive decline. The mechanism of Hcy neurotoxicity in the brain is controversial as well Hcy is a ligand of NMDA receptor. Memantine, an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors approved for the treatment of moderate to severe ...

متن کامل

Opium Induces Apoptosis in Jurkat Cells

Background: The direct effect of some opioids on immune cells has been demonstrated. The aim of this study was to assess the apoptotic effect of opium on Jurkat T lymphocyte cells. Methods: Different concentrations of opium (2.86 × 10-3 to 2.86 × 10-11 g/ml) were added to 24-well plates containing 5 × 105 Jurkat cells. Apoptotic events were assessed after 6, 24, and 72 hours by flow-cytometric...

متن کامل

Intrapallidal lipopolysaccharide injection increases iron and ferritin levels in glia of the rat substantia nigra and induces locomotor deficits.

Increasing evidence suggests that abnormal iron handling may be involved in the pathogenesis of Parkinson's disease. The present study investigates the role of iron and the iron-storage protein ferritin in inflammation-induced degeneration of dopaminergic neurons of the substantia nigra pars compacta. Injection of lipopolysaccharide into the globus pallidus of young and middle-aged rats substan...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
international journal of molecular and cellular medicine

جلد ۲، شماره ۲، صفحات ۸۰-۸۵

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023